Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we
characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer …

Clonal evolution of a tumor ecosystem depends on different selection pressures that are
principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR …

Importance Despite evidence demonstrating an overall survival benefit with up-front
hormone therapy in addition to established synergy between hormone therapy and …

T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen
exposure and potential future response. However, despite advances in deep repertoire …

Background The powerful 'graft versus leukemia'effect thought partly responsible for the
therapeutic effect of allogeneic hematopoietic cell transplantation in acute myeloid leukemia …

Acute cellular rejection is common after lung transplantation and is associated with an
increased risk of early chronic rejection. We present combined single-cell RNA and TCR …

Purpose: LTX-315 is a first-in-class, 9-mer membranolytic peptide that has shown potent
immunomodulatory properties in preclinical models. We conducted a phase I dose …

Clinical studies combining radiation and immunotherapy have shown promising response
rates, strengthening efforts to sensitize tumors to immune-mediated attack. Thus, there is an …

Background Expressed on activated T and natural killer cells, 4-1BB/CD137 is a
costimulatory receptor that signals a series of events resulting in cytokine secretion and …

Abstract The phase III JAVELIN Renal 101 trial demonstrated prolonged progression-free
survival (PFS) in patients (N= 886) with advanced renal cell carcinoma treated with first-line …