Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon
skeletons, osmolytes, signals, and transient energy storage and as transport molecules …

Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5.
This family includes 12 different members in human that mediate the transport of sugars …

ABSTRACT Sodium glucose cotransporter 2 (SGLT2) inhibitors have been reported to lower
the serum uric acid (SUA) level. To elucidate the mechanism responsible for this reduction …

Hyperglycemia is the primary factor responsible for the microvascular, and to a lesser extent
macrovascular, complications of diabetes. Despite this well-established relationship …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0
mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction …

SGLT2 (sodium-glucose cotransporter 2) inhibitors are a new class of antihyperglycaemic
drugs that act on the proximal tubules of the kidney. They have shown efficacy in the …

Coincident with the high and increasing worldwide prevalence of type 2 diabetes (T2D), a
growing armamentarium of antidiabetes medications has been introduced to target different …

In the kidney, glucose in glomerular filtrate is reabsorbed primarily by sodium-glucose
cotransporters 1 (SGLT1) and 2 (SGLT2) along the proximal tubules. SGLT2 has been …

The importance of uric acid, the final metabolite of purines excreted by the kidneys and
intestines, was not previously recognized, except for its role in forming crystals in the joints …