The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Pancreatic cancer exhibits a unique bioarchitecture and desmoplastic cancer-stoma
interplay that governs disease progression, multi-resistance, and metastasis. Emulating the …

Cell migration during many fundamental biological processes including metastasis requires
cells to traverse tissue with heterogeneous mechanical cues that direct migration as well as …

The establishment of organotypic preclinical models that accurately resemble the native
tumor microenvironment at an anatomic human scale is highly desirable to level up in vitro …

Cell migration is essential for a variety of biological processes, such as embryogenesis,
wound healing, and the immune response. After more than a century of research—mainly on …

The extracellular matrix is an organized three-dimensional network of protein-based
molecules and other macromolecules that provide structural and biochemical support to …

The tumor microenvironment is an interacting heterogeneous collection of cancer cells,
resident as well as infiltrating host cells, secreted factors, and extracellular matrix proteins …

This book provides information about different types and stages of cancer and their subtypes
with their respective molecular mechanisms, etiology, histopathology, and cellular origins …