In recent years, much progress has been motivated in stimuli-responsive nanocarriers,
which could response to the intrinsic physicochemical and pathological factors in diseased …

Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

The abundant glutathione (GSH) in “cold” tumors weakens ferroptosis therapy and the
immune response. Inspired by lipids, we fabricated cinnamaldehyde dimers (CDC) into lipid …

Design of endogenous stimuli-responsive amino acids allows for precisely modulating
proteins or peptides under a biological microenvironment and thereby regulating their …

Allosteric transitions can modulate the self‐assembly and biological function of proteins. It
remains, however, tremendously challenging to design synthetic allosteric polymeric …

Peptidomimetic polymers have attracted increasing interest because of the advantages of
facile synthesis, high molecular tunability, resistance to degradation, and low …

The manipulation of the flexibility/rigidity of polymeric chains to control their function is
commonly observed in natural macromolecules but largely unexplored in synthetic systems …

Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that
have found broad biomedical applications. Ring-opening polymerization of N …

Controlled drug delivery systems, which could release loaded therapeutics upon
physicochemical changes imposed by physiological triggers in the desired zone and during …

Reactive oxygen species (ROS) play an essential role in regulating various physiological
functions of living organisms; however, as the concentration of ROS increases in the area of …