The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

The development of new antibacterial agents to combat worsening antibiotic resistance is
still a priority area in anti-infectives research, but in the post-genomic era it has been more …

Plant byproducts and waste present enormous environmental challenges and an
opportunity for valorization and industrial application. Due to consumer demands for natural …

Peptidoglycan is the major component of the cell envelope of virtually all bacteria. It has
structural roles and acts as a selective sieve for molecules from the outer environment …

This review is an attempt to bring together and critically evaluate the now-abundant but
dispersed data concerning the lipid intermediates of the biosynthesis of bacterial …

In Escherichia coli many enzymes including MurG are directly involved in the synthesis and
assembly of peptidoglycan. MurG is an essential glycosyltransferase catalysing the last …

Scintillation proximity assays (SPAs) have become a powerful tool for high-throughput
screening (HTS) because they can measure the activity and binding of very diverse classes …

Proteins involved in bacterial cell division often do not have a counterpart in eukaryotic cells
and they are essential for the survival of the bacteria. The genetic accessibility of many …

Whether the bacterial cell wall remains a viable source of novel antibacterials is addressed
here by reviewing screen and design strategies for discovery of antibacterials with a focus …

MurG (Rv2153c) is a key player in the biosynthesis of the peptidoglycan layer in
Mycobacterium tuberculosis (Mtb). This work is an attempt to highlight the structural and …