Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder
AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
Strategies for improvement of gamma-aminobutyric acid (GABA) biosynthesis via lactic acid bacteria (LAB) fermentation
S Pannerchelvan, L Rios-Solis, FWF Wong… - Food & Function, 2023 - pubs.rsc.org
Gamma-aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature
and extensively explored for its numerous physiological functions and effects on metabolic …
and extensively explored for its numerous physiological functions and effects on metabolic …
[HTML][HTML] Zuranolone in major depressive disorder: results from MOUNTAIN—a phase 3, multicenter, double-blind, randomized, placebo-controlled trial
AH Clayton, R Lasser, I Nandy, AJ Sankoh… - The Journal of …, 2023 - psychiatrist.com
Objective: To evaluate the efficacy and safety of zuranolone, an investigational neuroactive
steroid and GABA A receptor positive allosteric modulator, in major depressive disorder …
steroid and GABA A receptor positive allosteric modulator, in major depressive disorder …
Impact of environmental pollutants on gut microbiome and mental health via the gut–brain axis
Over the last few years, the microbiome has emerged as a high-priority research area to
discover missing links between brain health and gut dysbiosis. Emerging evidence suggests …
discover missing links between brain health and gut dysbiosis. Emerging evidence suggests …
Anxiety and depression: A top‐down, bottom‐up model of circuit function
DO LeDuke, M Borio, R Miranda… - Annals of the New York …, 2023 - Wiley Online Library
A functional interplay of bottom‐up and top‐down processing allows an individual to
appropriately respond to the dynamic environment around them. These processing …
appropriately respond to the dynamic environment around them. These processing …
Dextromethorphan-bupropion for the treatment of depression: a systematic review of efficacy and safety in clinical trials
Background A significant proportion of adults with major depressive disorder (MDD) do not
respond to treatments which are currently used in clinical practice such as first-generation …
respond to treatments which are currently used in clinical practice such as first-generation …
Clinical and preclinical studies of fermented foods and their effects on Alzheimer's disease
MR Kumar, NF Azizi, SK Yeap, JO Abdullah, M Khalid… - Antioxidants, 2022 - mdpi.com
The focus on managing Alzheimer's disease (AD) is shifting towards prevention through
lifestyle modification instead of treatments since the currently available treatment options are …
lifestyle modification instead of treatments since the currently available treatment options are …
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research
S Lv, K Yao, Y Zhang, S Zhu - Neuropharmacology, 2023 - Elsevier
Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
Is depression the missing link between inflammatory mediators and cancer?
B Polityńska, O Pokorska, AM Wojtukiewicz… - Pharmacology & …, 2022 - Elsevier
Patients with cancer are at greater risk of developing depression in comparison to the
general population and this is associated with serious adverse effects, such as poorer …
general population and this is associated with serious adverse effects, such as poorer …
Efficacy and safety of zuranolone co-initiated with an antidepressant in adults with major depressive disorder: results from the phase 3 CORAL study
Major depressive disorder (MDD) is a mental health disorder that can cause disability and
functional impairment that standard-of-care (SOC) antidepressant therapies (ADTs) can take …
functional impairment that standard-of-care (SOC) antidepressant therapies (ADTs) can take …