In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and
primary sclerosing cholangitis (PSC), are manifested as an impairment of normal bile flow …

The identification of the key regulators of bile acid (BA) synthesis and transport within the
enterohepatic circulation has revealed potential targets for pharmacological therapies of …

Gallstone disease is a common pathology of the digestive system with nearly a 10–20%
incidence rate among adults. The mainstay of treatment is cholecystectomy, which is …

Background Bile acids are important endocrine modulators of intestinal and hepatic
signalling cascades orchestrating critical pathophysiological processes in various liver …

Bile acids (BA) are amphiphilic molecules synthesized in the liver (primary BA) starting from
cholesterol. In the small intestine, BA act as strong detergents for emulsification …

The main trigger for liver injury in acquired cholestatic liver disease remains unclear.
However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in …

Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …

Background & Aims As the composition of the bile acid (BA) pool has a major impact on liver
pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled …