Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is
indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to …

Calming the cytokine storm in COVID-19 | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …

Background: It was studied if early suPAR-guided anakinra treatment can prevent severe
respiratory failure (SRF) of COVID-19. Methods: A total of 130 patients with suPAR≥ 6 ng/ml …

The coronavirus disease 2019 (COVID-19) pandemic has infected> 22.7 million and led to
the deaths of 795,000 people worldwide. Patients with diabetes are highly susceptible to …

Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its
pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the …

Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease
2019 (COVID-19) for reasons that are unclear. RESEARCH DESIGN AND METHODS We …