Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

The metabolic characteristics of tumors present considerable hurdles to immune cell
function and cancer immunotherapy. Using a glutamine antagonist, we metabolically …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as
a promising target for cancer therapy. However, efforts to drug this process are confounded …

Cancer-associated fibroblasts (CAFs) are one of the most prominent and active components
in the pancreatic tumor microenvironment. Our data show that CAFs are critical for survival …

Transcription factors of the MYC family are deregulated in the majority of all human cancers.
Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the
regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant …

The concept that cancer is a metabolic disease is now well acknowledged: many cancer cell
types rely mostly on glucose and some amino acids, especially glutamine for energy supply …