BACKGROUND Autophagy is an intracellular catabolic process of degrading and recycling
proteins and organelles to modulate various physiological and pathological events …

Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome that presents with
diverse and complex clinical features and involves multiple human systems. TSC-related …

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …

Huntington's disease (HD) is a genetic progressive neurodegenerative disorder, caused by
a mutation in the HTT gene, for which there is currently no cure. The identification of …

COX7A1, a subunit of cytochrome c oxidase, holds an important position in the super-
assembly which integrates into multi-unit heteromeric complexes peripherally in the …

Acne vulgaris is a chronic, inflammatory, skin condition that involves the pilosebaceous
follicles and is influenced by a variety of factors including genetics, androgen-stimulation of …

Cumulative UV radiation (UVR) exposure plays a critical role in photoaging,
immunosuppression, photocarcinogenesis and the exacerbation of photodermatoses. UV-A …

The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling
pathway has been implicated as a cancer target. Big pharma players and small companies …

Background The treatment of tuberous sclerosis complex (TSC) using mammalian target of
rapamycin (mTOR) inhibitors is clinically promising. The aim of the present study was to …

Abstract Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading
to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and lesions in …