Microbial lipases and their potential in the production of pharmaceutical building blocks
Processes involving lipases in obtaining active pharmaceutical ingredients (APIs) are crucial
to increase the sustainability of the industry. Despite their lower production cost, microbial …
to increase the sustainability of the industry. Despite their lower production cost, microbial …
Evaluation of antibacterial activity against nosocomial pathogens of an enzymatically derived α-aminophosphonates possessing coumarin scaffold
P Kowalczyk, D Koszelewski, A Brodzka… - International Journal of …, 2023 - mdpi.com
The purpose of the present study was to evaluate the synergistic effect of two important
pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial …
pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial …
Synthesis of Novel 1,3,4-Oxadiazole-Derived α-Aminophosphonates/α-Aminophosphonic Acids and Evaluation of Their In Vitro Antiviral Activity against the Avian …
S Hkiri, M Mekni-Toujani, E Üstün, K Hosni, A Ghram… - Pharmaceutics, 2022 - mdpi.com
An efficient and simple approach has been developed for the synthesis of eight dialkyl/aryl
[(5-phenyl-1, 3, 4-oxadiazol-2-ylamino)(aryl) methyl] phosphonates through the Pudovik …
[(5-phenyl-1, 3, 4-oxadiazol-2-ylamino)(aryl) methyl] phosphonates through the Pudovik …
Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates
J Samsonowicz-Górski, D Koszelewski… - International Journal of …, 2022 - mdpi.com
An enzymatic route for phosphorous–carbon bond formation was developed by discovering
new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the …
new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the …
Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains
D Koszelewski, P Kowalczyk, A Brodzka… - International Journal of …, 2023 - mdpi.com
The objective of the present study was to evaluate the synergistic effect of two important
pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial …
pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial …
Inhibition Profiles of Some Novel Sulfonamide-Incorporated α-Aminophosphonates on Human Carbonic Anhydrases
A series of hitherto unknown sulfonamide-incorporated α-aminophosphonate derivatives
were synthesized through the one-pot, two-step FeCl3-catalyzed coupling of 4 …
were synthesized through the one-pot, two-step FeCl3-catalyzed coupling of 4 …
Box–Behnken design for the optimisation of Kabachnik–Fields reaction catalysed by natural kaolinite clay under eco-friendly conditions
M Boukachabia, S Guezane-Lakoud… - Reaction Chemistry & …, 2024 - pubs.rsc.org
Natural kaolin has been employed as an efficient, simple, and environmentally friendly
catalyst for the synthesis of α-aminophosphonates by a multicomponent condensation …
catalyst for the synthesis of α-aminophosphonates by a multicomponent condensation …
Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to …
D Koszelewski, P Kowalczyk… - International Journal of …, 2023 - mdpi.com
A mild and efficient protocol for the synthesis of p-quinols under aqueous conditions was
developed. The pivotal role of additives in the copper-catalyzed addition of aryl boronic and …
developed. The pivotal role of additives in the copper-catalyzed addition of aryl boronic and …
Enantioselective synthesis of α-aryl α-hydrazino phosphonates
S Alberca, J Romero-Parra, I Fernández… - Chemical …, 2024 - pubs.rsc.org
Catalysts generated in situ by the combination of pyridine–hydrazone N, N-ligands and Pd
(TFA) 2 have been applied to the addition of arylboronic acids to formylphosphonate-derived …
(TFA) 2 have been applied to the addition of arylboronic acids to formylphosphonate-derived …
The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents
A Brodzka, P Kowalczyk, D Trzepizur, D Koszelewski… - Molecules, 2022 - mdpi.com
The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on
cytotoxic activity was studied. The organophosphonates were obtained based on developed …
cytotoxic activity was studied. The organophosphonates were obtained based on developed …