Microbial lipases and their potential in the production of pharmaceutical building blocks

CA Godoy, JS Pardo-Tamayo, O Barbosa - International Journal of …, 2022 - mdpi.com
Processes involving lipases in obtaining active pharmaceutical ingredients (APIs) are crucial
to increase the sustainability of the industry. Despite their lower production cost, microbial …

Evaluation of antibacterial activity against nosocomial pathogens of an enzymatically derived α-aminophosphonates possessing coumarin scaffold

P Kowalczyk, D Koszelewski, A Brodzka… - International Journal of …, 2023 - mdpi.com
The purpose of the present study was to evaluate the synergistic effect of two important
pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial …

Synthesis of Novel 1,3,4-Oxadiazole-Derived α-Aminophosphonates/α-Aminophosphonic Acids and Evaluation of Their In Vitro Antiviral Activity against the Avian …

S Hkiri, M Mekni-Toujani, E Üstün, K Hosni, A Ghram… - Pharmaceutics, 2022 - mdpi.com
An efficient and simple approach has been developed for the synthesis of eight dialkyl/aryl
[(5-phenyl-1, 3, 4-oxadiazol-2-ylamino)(aryl) methyl] phosphonates through the Pudovik …

Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates

J Samsonowicz-Górski, D Koszelewski… - International Journal of …, 2022 - mdpi.com
An enzymatic route for phosphorous–carbon bond formation was developed by discovering
new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the …

Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on Selected E. coli Strains

D Koszelewski, P Kowalczyk, A Brodzka… - International Journal of …, 2023 - mdpi.com
The objective of the present study was to evaluate the synergistic effect of two important
pharmacophores, coumarin and α-amino dimethyl phosphonate moieties, on antimicrobial …

Inhibition Profiles of Some Novel Sulfonamide-Incorporated α-Aminophosphonates on Human Carbonic Anhydrases

M Sobati, M Abdoli, A Bonardi, P Gratteri… - ACS Medicinal …, 2023 - ACS Publications
A series of hitherto unknown sulfonamide-incorporated α-aminophosphonate derivatives
were synthesized through the one-pot, two-step FeCl3-catalyzed coupling of 4 …

Box–Behnken design for the optimisation of Kabachnik–Fields reaction catalysed by natural kaolinite clay under eco-friendly conditions

M Boukachabia, S Guezane-Lakoud… - Reaction Chemistry & …, 2024 - pubs.rsc.org
Natural kaolin has been employed as an efficient, simple, and environmentally friendly
catalyst for the synthesis of α-aminophosphonates by a multicomponent condensation …

Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to …

D Koszelewski, P Kowalczyk… - International Journal of …, 2023 - mdpi.com
A mild and efficient protocol for the synthesis of p-quinols under aqueous conditions was
developed. The pivotal role of additives in the copper-catalyzed addition of aryl boronic and …

Enantioselective synthesis of α-aryl α-hydrazino phosphonates

S Alberca, J Romero-Parra, I Fernández… - Chemical …, 2024 - pubs.rsc.org
Catalysts generated in situ by the combination of pyridine–hydrazone N, N-ligands and Pd
(TFA) 2 have been applied to the addition of arylboronic acids to formylphosphonate-derived …

The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents

A Brodzka, P Kowalczyk, D Trzepizur, D Koszelewski… - Molecules, 2022 - mdpi.com
The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on
cytotoxic activity was studied. The organophosphonates were obtained based on developed …