High‐Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes

T Costacou, T Vaisar, RG Miller… - Journal of the …, 2024 - ahajournals.org
Background The cholesterol efflux capacity of high density lipoprotein (HDL) is negatively
associated with cardiovascular risk. Small HDL particles account almost quantitatively for …

Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis

V Kothari, TWW Ho, AG Cabodevilla, Y He… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Individuals with type 1 diabetes (T1D) generally have normal or even
higher HDL (high-density lipoprotein)-cholesterol levels than people without diabetes yet …

Library screening identifies commercial drugs as potential structure correctors of abnormal apolipoprotein AI

C Gkolfinopoulou, A Bourtsala, D Georgiadou… - Journal of Lipid …, 2024 - ASBMB
AapoA-I, the main protein of high-density lipoprotein, plays a key role in the biogenesis and
atheroprotective properties of high-density lipoprotein. We showed previously that a …

miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1

Z Ou, Y Cheng, H Ma, K Chen, Q Lin, J Chen… - Journal of Translational …, 2024 - Springer
Background Spinal cord injury (SCI) is characterized by extensive demyelination and
inflammatory responses. Facilitating the clearance of lipid droplets (LDs) within microglia …

Does small HDL's function improve when lipid-lowering alters its composition?

JW Heinecke, T Vaisar, KE Bornfeldt - Journal of Lipid Research, 2024 - ASBMB
Metabolic syndrome associates with a markedly increased risk for cardiovascular disease
(CVD) and very frequently with dyslipidemia, which is characterized by elevated plasma …

Quantification of high-density lipoprotein particle number by proton nuclear magnetic resonance: don't believe the numbers

T Vaisar, J Heinecke - Current Opinion in Lipidology - journals.lww.com
NMR is a low-cost method for quantifying HDL-P that is readily applicable to clinical and
translational studies. However, inconsistencies between the results of NMR quantification of …