Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Mutations affecting ciliary components cause ciliopathies. As described here, we
investigated Tectonic1 (Tctn1), a regulator of mouse Hedgehog signaling, and found that it is …

Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic
disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects …

Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal
end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia …

Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis.
Inheritance of the mother centriole, which nucleates the primary cilium, in relation to …

S-palmitoylation describes the reversible attachment of fatty acids (predominantly palmitate)
onto cysteine residues via a labile thioester bond. This posttranslational modification …