Introduction Ischemic heart diseases, especially the myocardial infarction, is a major hazard
problem to human health. Despite substantial advances in control of risk factors and …

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac
function in patients affected by heart disease or heart failure. CPCs are proliferative and …

Whereas cardiac-derived c-kit+ stem cells (CSCs) and bone marrow-derived mesenchymal
stem cells (MSCs) are undergoing clinical trials testing safety and efficacy as a cell-based …

The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the
heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key …

This study investigates the characteristics of cardiac mesenchymal stem cell-like cells
(CMSCLCs) isolated from the right atrial appendage of human donors with ischemia and a …

Abstract Cardiac “side population”(SP) cells have previously been found to differentiate into
both endothelial cells and cardiomyocytes in mice and rats, but there are no data on SP cells …

The heart has a limited ability to regenerate. It is important to identify therapeutic strategies
that enhance cardiac regeneration in order to replace cardiomyocytes lost during the …

Despite advances in treatment, heart failure remains one of the top killers in Canada. This
recognition motivated a new research focus to harness the fundamental repair properties of …

The adult mammalian heart has a limited regenerative capacity. Therefore, identification of
endogenous cells and mechanisms that contribute to cardiac regeneration is essential for …

Cardiomyocyte proliferation has emerged as the main source of new cardiomyocytes in the
adult. Progenitor cell populations may on the other hand contribute to the renewal of other …