Large-vessel vasculitis (LVV) manifests as inflammation of the aorta and its major branches
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions …

While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …

Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke,
aortic arch syndrome, and aortic aneurysm. The disease is often refractory to …

Background: Giant cell arteritis, a chronic autoimmune disease of the aorta and its large
branches, is complicated by aneurysm formation, dissection, and arterial occlusions. Arterial …

Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

Abstract Purpose of Review Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are auto-
inflammatory and autoimmune diseases with a highly selective tissue tropism for medium …

The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also
known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor …

Rationale: Giant cell arteritis (GCA)—a primary vasculitis of medium and large arteries—is
associated with vessel wall damage, elastic membrane fragmentation, and vascular …

Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the
acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown …