Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

Iron is an essential element in biology, required for numerous cellular processes. Either too
much or too little iron can be detrimental, and organisms have developed mechanisms for …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …

Human hepcidin, a 25–amino acid peptide made by hepatocytes, may be a new mediator of
innate immunity and the long-sought iron-regulatory hormone. The synthesis of hepcidin is …

Macrophages are sentinel cells of the innate immune system and have important functions
in development, tissue homeostasis, and immunity. These phylogenetically ancient cells …