[HTML][HTML] Review on the computational genome annotation of sequences obtained by next-generation sequencing
GF Ejigu, J Jung - Biology, 2020 - mdpi.com
Simple Summary Due to the development of high-throughput sequencing technologies,
computational genome annotation of sequences has become one of the principal research …
computational genome annotation of sequences has become one of the principal research …
KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis
Gene set enrichment (GSE) analysis plays an essential role in extracting biological insight
from genome-scale experiments. ORA (overrepresentation analysis), FCS (functional class …
from genome-scale experiments. ORA (overrepresentation analysis), FCS (functional class …
[HTML][HTML] NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Hepatocellular carcinoma (HCC) can have viral or non-viral causes,,,–. Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …
[HTML][HTML] Innate immune training of granulopoiesis promotes anti-tumor activity
Trained innate immunity, induced via modulation of mature myeloid cells or their bone
marrow progenitors, mediates sustained increased responsiveness to secondary …
marrow progenitors, mediates sustained increased responsiveness to secondary …
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
The mechanisms that drive nonalcoholic fatty liver disease (NAFLD) remain incompletely
understood. This large multicenter study characterized the transcriptional changes that occur …
understood. This large multicenter study characterized the transcriptional changes that occur …
Immune-evasive human islet-like organoids ameliorate diabetes
Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but
there remain challenges towards achieving this goal,,,,–. Here we generate human islet-like …
there remain challenges towards achieving this goal,,,,–. Here we generate human islet-like …
Altered cardiac energetics and mitochondrial dysfunction in hypertrophic cardiomyopathy
S Ranjbarvaziri, KB Kooiker, M Ellenberger, G Fajardo… - Circulation, 2021 - Am Heart Assoc
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …
Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury
LMS Gerhardt, J Liu, K Koppitch… - Proceedings of the …, 2021 - National Acad Sciences
Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Computational single-cell RNA-seq (scRNA-seq) methods have been successfully applied
to experiments representing a single condition, technology, or species to discover and …
to experiments representing a single condition, technology, or species to discover and …
[HTML][HTML] A single-cell transcriptome atlas of the aging Drosophila brain
K Davie, J Janssens, D Koldere, M De Waegeneer… - Cell, 2018 - cell.com
The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …