The discovery 30 years ago that inflammatory cytokines cause a concentration, activity, and
time-dependent bimodal response in pancreatic β-cell function and viability has been a …

Since their discovery nearly five decades ago, molecular scaffolds belonging to the 14-3-3
protein family have been recognized as pleiotropic regulators of diverse cellular and …

Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state.
Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states …

The proteins that coordinate complex adipogenic transcriptional networks are poorly
understood. 14-3-3ζ is a molecular adaptor protein that regulates insulin signalling and …

While critical for neurotransmitter synthesis, 14-3-3 proteins are often assumed to have
redundant functions due to their ubiquitous expression, but despite this assumption, various …

Recent studies demonstrate that α cells contribute to glucose-stimulated insulin secretion
(GSIS). Glucagon-like peptide-1 receptor (GLP-1R) agonists potently potentiate GSIS …

Metabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's
microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction …

Curcumin has potential anticancer activity and has been shown to be involved in several
signaling pathways including differentiation and apoptosis. Our previous study showed that …

Maternal lipolytic metabolic disorders result in a lipotoxic microenvironment in the ovarian
follicular fluid (FF) which deteriorates oocyte quality. Although cellular stress response …

Obesity entails metabolic alterations across multiple organs, highlighting the role of inter-
organ communication in its pathogenesis. Extracellular vesicles (EVs) are communication …