For multiple intracellular bacterial pathogens, the ability to spread directly into adjacent
epithelial cells is an essential step for disease in humans. For pathogens such as Shigella …

Piezo1 is a mechanosensitive Ca2+-permeable channel that has been implicated in a
number of mechanosensing processes. It is diffusive on plasma membranes and activated …

Vinculin is a cytoskeletal linker strengthening cell adhesion. The Shigella IpaA invasion
effector binds to vinculin to promote vinculin supra-activation associated with head-domain …

Shigella, the causative agent of bacillary dysentery, invades epithelial cells to colonize the
intestinal mucosa. Following invasion, Shigella is enclosed in a vacuole that needs to …

Isoform switching of cytoskeletal proteins help muscle cells to adapt various physiological
needs. However, their involvement in deciphering differentiation signals into myogenic …

Vinculin is a cytoskeletal linker of integrin-mediated matrix adhesions and cadherin-based
cell-cell junctions (Goldman, 2016; Bays & DeMali, 2017). It plays an important role in cell …

Shigella, the causative agent of bacillary dysentery, invades epithelial cells to colonize the
intestinal mucosa. Following invasion, Shigella is enclosed in a vacuole that needs to …

Mechanosensing is an integral part of many physiological processes including stem cell
differentiation, fibrosis and cancer progression. Two major mechanosensing systems–focal …

Vinculin is a protein associated to linking adhesion receptors facing the outside of cells and
reinforcing them by linking it's intracellular domain of those receptors or, in the case of Cell …

Vinculin is a protein associated to reinforce integrin adhesion structures. The protein's D1
and D5 subdomains have been extensively studied for its binding capacity to VBSs and F …