Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Ubiquitin-conjugating enzyme 2C (UBE2C) participates in cell cycle progression and
checkpoint control by targeted degradation of short-lived proteins. As a conjugating enzyme …

Background and Objective: Non-small cell lung cancer (NSCLC) accounts for 80–85% of all
patients with lung cancer and 5-year relative overall survival (OS) rate is less than 20%, so …

Since the five-year survival rate is less than 5%, pancreatic ductal adenocarcinoma (PDAC)
remains the 4th cause of cancer-related death. Although PDAC has been repeatedly …

Background: Ubiquitin-conjugating enzyme E2C (UBE2C) has been shown to be associated
with the occurrence of various cancers and involved in many tumorigenic processes. This …

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous tumor that the underlying
molecular mechanisms are largely unclear. This study aimed to elucidate the key candidate …

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as
it represents a major obstacle to effective cancer treatment. Since tumor cells are highly …

Jiwei Guo a,⁎, 1, Dan Jin b, 1, Yan Wu a, Lijuan Yang a, Jing Du a, Kaikai Gong a, Weiwei
Chen a, Juanjuan Dai a, Shuang Miao a, Sichuan Xi aa Cancer research institute, Binzhou …

Objective—Calcific aortic valve (AV) disease, characterized by AV sclerosis and
calcification, is a major cause of death in the aging population; however, there are no …

Proteasomes are multicatalytic protease complexes in the cell, involved in the non-
lysosomal recycling of intra-cellular proteins. Proteasomes play a critical role in regulation of …