To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

tRNA molecules undergo extensive post-transcriptional processing to generate the mature
functional tRNA species that are essential for translation in all organisms. These processing …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

Proteins with knotted configurations, in comparison with unknotted proteins, are restricted in
conformational space. Little is known regarding whether knotted proteins have sufficient …

Defective nucleotide modifications of mitochondrial tRNAs have been associated with
several human diseases, but their pathophysiology remains poorly understood. In this …

Defects in the posttranscriptional modifications of mitochondrial tRNAs have been linked to
human diseases, but their pathophysiology remains elusive. In this report, we investigated …

Abstract tRNA precursors undergo a maturation process, involving nucleotide modifications
and folding into the L-shaped tertiary structure. The N 1-methylguanosine at position 37 …

ABSTRACT tRNAs play a critical role in mRNA decoding, and posttranscriptional
modifications within tRNAs drive decoding efficiency and accuracy. The types and positions …

To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes
have been identified not only in thermophiles but also in mesophiles. Because most …

The deep trefoil knot architecture is unique to the SpoU and tRNA methyltransferase D
(TrmD)(SPOUT) family of methyltransferases (MTases) in all three domains of life. In …