Alzheimer's disease (AD) is a progressive neurodegenerative disease. Although it has been
studied for years, the pathogenesis of AD is still controversial. Genetic factors may play an …

Alzheimer's disease (AD) is a complex neurological disorder of uncertain aetiology,
although substantial research has been conducted to explore important factors related to …

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …

The kidney and brain expressed protein (KIBRA) plays an important role in synaptic
plasticity. Carriers of the T allele of the KIBRA (WWC1) gene rs17070145 C/T polymorphism …

Objective: Although heritability explains a large proportion of the variance in old-age
cognition, studies on the influence of specific genes have been inconclusive. We …

Objective To prospectively examine 8-year risk of clinical disease progression to mild
cognitive impairment (MCI)/dementia in older adults≥ 60 with superior episodic memory …

Objectives High-intensity exercise is a potential therapeutic tool to postpone or prevent the
onset of cognitive decline. However, there is a lack of sufficient evidence regarding the …

Introduction Superior cognitive performance in older adults may reflect underlying resistance
to age‐associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has …

The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously
been associated with cognition and rates of cognitive decline. This study aimed to determine …

Background: With the exception of APOE, genetic variants associated with increased
Alzheimer's disease (AD) risk are characterized by small effect sizes. Polygenic risk scores …