The evolutionary origin of host association in the Rickettsiales
The evolution of obligate host-association of bacterial symbionts and pathogens remains
poorly understood. The Rickettsiales are an alphaproteobacterial order of obligate …
poorly understood. The Rickettsiales are an alphaproteobacterial order of obligate …
Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors
By catalyzing oxidative protein folding, the bacterial disulfide bond protein A (DsbA) plays an
essential role in the assembly of many virulence factors. Predictably, DsbA disruption affects …
essential role in the assembly of many virulence factors. Predictably, DsbA disruption affects …
Life inside and out: making and breaking protein disulfide bonds in Chlamydia
S Christensen, RM McMahon, JL Martin… - Critical reviews in …, 2019 - Taylor & Francis
Disulphide bonds are widely used among all domains of life to provide structural stability to
proteins and to regulate enzyme activity. Chlamydia spp. are obligate intracellular bacteria …
proteins and to regulate enzyme activity. Chlamydia spp. are obligate intracellular bacteria …
The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance
The human pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) contains
a complex disulfide bond (Dsb) catalytic machinery. This machinery encompasses multiple …
a complex disulfide bond (Dsb) catalytic machinery. This machinery encompasses multiple …
Disulfide isomerase activity of the dynamic, trimeric Proteus mirabilis ScsC protein is primed by the tandem immunoglobulin-fold domain of ScsB
EJ Furlong, HG Choudhury, F Kurth, AP Duff… - Journal of Biological …, 2018 - ASBMB
Correct disulfide bond formation is essential for proper folding of many proteins, including
bacterial virulence factors. The suppressor of copper sensitivity (Scs) proteins have roles in …
bacterial virulence factors. The suppressor of copper sensitivity (Scs) proteins have roles in …
Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase
The Gram negative bacteria Chlamydia trachomatis is an obligate intracellular human
pathogen that can cause pelvic inflammatory disease, infertility and blinding trachoma. C …
pathogen that can cause pelvic inflammatory disease, infertility and blinding trachoma. C …
Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and …
S Christensen, MA Halili, N Strange, GA Petit… - PLoS …, 2019 - journals.plos.org
Chlamydia trachomatis is an obligate intracellular bacterium with a distinctive biphasic
developmental cycle that alternates between two distinct cell types; the extracellular …
developmental cycle that alternates between two distinct cell types; the extracellular …
The evolutionary origin of host association in an ancient bacterial clade
The evolution of obligate host-association of bacterial symbionts and pathogens remains
poorly understood. The Rickettsiales represent an order of obligate alphaproteobacterial …
poorly understood. The Rickettsiales represent an order of obligate alphaproteobacterial …
Engineering of the Dsb (disulfide bond) proteins–contribution towards understanding their mechanism of action and their applications in biotechnology and medicine
AM Banaś, KM Bocian-Ostrzycka… - Critical reviews in …, 2019 - Taylor & Francis
The Dsb protein family in prokaryotes catalyzes the generation of disulfide bonds between
thiol groups of cysteine residues in nascent proteins, ensuring their proper three …
thiol groups of cysteine residues in nascent proteins, ensuring their proper three …
[PDF][PDF] The atypical thiol–disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase
PM Walden, AE Whitten, L Premkumar… - … Section D: Structural …, 2019 - journals.iucr.org
Disulfide-bond-forming (DSB) oxidative folding enzymes are master regulators of virulence
that are localized to the periplasm of many Gram-negative bacteria. The archetypal DSB …
that are localized to the periplasm of many Gram-negative bacteria. The archetypal DSB …