Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
mTOR: Role in cancer, metastasis and drug resistance
AK Murugan - Seminars in cancer biology, 2019 - Elsevier
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …
[HTML][HTML] Updated international tuberous sclerosis complex diagnostic criteria and surveillance and management recommendations
Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …
Targeting the PI3K pathway in cancer: are we making headway?
F Janku, TA Yap, F Meric-Bernstam - Nature reviews Clinical oncology, 2018 - nature.com
Abstract The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated
pathways in cancer and, consequently, more than 40 compounds that target key …
pathways in cancer and, consequently, more than 40 compounds that target key …
The PI3K pathway in human disease
DA Fruman, H Chiu, BD Hopkins, S Bagrodia… - Cell, 2017 - cell.com
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
NCCN guidelines insights: kidney cancer, version 1.2021: featured updates to the NCCN guidelines
The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for
diagnostic workup, staging, and treatment of patients with renal cell carcinoma (RCC) …
diagnostic workup, staging, and treatment of patients with renal cell carcinoma (RCC) …
Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management
Lymphangioleiomyomatosis (LAM) is a slowly progressive, low-grade, metastasising
neoplasm of women, characterised by infiltration of the lung parenchyma with abnormal …
neoplasm of women, characterised by infiltration of the lung parenchyma with abnormal …
Research progress of mTOR inhibitors
Y Chen, X Zhou - European journal of medicinal chemistry, 2020 - Elsevier
Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
[HTML][HTML] Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind …
Background Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used
for various benign tumours associated with tuberous sclerosis complex. We assessed the …
for various benign tumours associated with tuberous sclerosis complex. We assessed the …
Tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …