Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move
across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly …

Failure to recognize important features of a drug's pharmacokinetic characteristics is a key
cause of inappropriate dose and schedule selection, and can lead to reduced efficacy and …

Transporters contribute to renal elimination of drugs; therefore drug disposition can be
impacted if transporters are inhibited by comedicant drugs. Regulatory agencies have …

Pentacyclic triterpenes, including betulin, are widespread natural products with various
pharmacological effects. These compounds are the starting material for the synthesis of …

The membrane transport of many cationic prescription drugs depends on facilitated transport
by organic cation transporters of which several members, including OCT2 (SLC22A2), are …

Over the last decade, significant progress been made in elucidating the role of membrane
transporters in altering drug disposition, with important toxicological consequences due to …

Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3), a splice variant of
the hepatic uptake transporter OATP1B3 (liver-type), is expressed in several tumor entities …

For more effective chemotherapy and targeted treatment of colorectal cancer, this study
seeks to develop chitosan (CH)-human serum albumin (HAS)-D-α-tocopheryl polyethylene …

Membrane transporters play a key role in determining the pharmacokinetic profile,
therapeutic safety, and efficacy of many chemotherapeutic drugs by regulating cellular influx …