Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors
Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have
been developed. The target compounds were synthesized and tested in vitro against four …
been developed. The target compounds were synthesized and tested in vitro against four …
Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies
BGM Youssif, MM Morcoss, S Bräse, M Abdel-Aziz… - Molecules, 2024 - mdpi.com
A new class of benzimidazole-based derivatives (4a–j, 5, and 6) with potential dual
inhibition of EGFR and BRAFV600E has been developed. The newly synthesized …
inhibition of EGFR and BRAFV600E has been developed. The newly synthesized …
Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity
2, 3, 4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized
by the reaction of 1, 4-disubstituted thiosemicarbazides with chloroacetone in ethyl …
by the reaction of 1, 4-disubstituted thiosemicarbazides with chloroacetone in ethyl …
Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E
Thiazole and thiazolidinone recur in a wide range of biologically active compounds that
reach different targets within the context of tumors and represent a promising starting point to …
reach different targets within the context of tumors and represent a promising starting point to …
Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAFV600E: Design, Synthesis, and Antiproliferative Activity
A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one
structures has been developed, with dual inhibitory actions on both EGFR and BRAFV600E …
structures has been developed, with dual inhibitory actions on both EGFR and BRAFV600E …