The transient receptor potential superfamily of ion channels (TRP channels) is widely
recognized for the roles its members play in sensory nervous systems. However, the …

The key players of calcium (Ca2+) homeostasis and Ca2+ signal generation, which are
Ca2+ channels, Ca2+/H+ antiporters, and Ca2+-ATPases, are present in all fungi. Their …

A distinct set of channels and transporters regulates the ion fluxes across the lysosomal
membrane. Malfunctioning of these transport proteins and the resulting ionic imbalance is …

Transient receptor potential (TRP) channels emerged in fungi as mechanosensitive
osmoregulators. The Saccharomyces cerevisiae vacuolar TRP yeast 1 (TRPY1) is the most …

Transient receptor potential (TRP) cation channels, which are conserved across mammals,
flies, fish, sea squirts, worms, and fungi, essentially contribute to cellular Ca 2+ signaling …

In eukaryotes, calcium not only is an essential mineral nutrient but also serves as an
intracellular second messenger that is necessary for many physiological processes …

The transport of Ca2+ across membranes precedes the fusion and fission of various lipid
bilayers. Yeast vacuoles under hyperosmotic stress become fragmented through fission …

By vacuolar patch-clamp and Ca 2+ imaging experiments, we show that the yeast vacuolar
transient receptor potential (TRPY) channel 1 is activated by cytosolic Ca 2+ and inhibited …

Regulating calcium ion (Ca2+) channels to improve the cell cycle and metabolism is a
promising technology, ensuring increased cell growth, differentiation, and/or productivity. In …

SNARE-mediated membrane fusion is regulated by the lipid composition of the engaged
bilayers. Lipid composition impacts fusion through direct protein lipid interactions or through …