Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

During immune challenge, T lymphocytes engage pathways of anabolic metabolism to
support clonal expansion and the development of effector functions. Here we report a critical …

Naive CD8+ T cells differentiating into effector T cells increase glucose uptake and shift from
quiescent to anabolic metabolism. Although much is known about the metabolism of …

Reliance on glutamine has long been considered to be a hallmark of cancer cell
metabolism. However, some recent studies have challenged this notion in vivo, prompting a …

T cell subsets including effector (T eff), regulatory (T reg), and memory (T mem) cells are
characterized by distinct metabolic profiles that influence their differentiation and function …

Metabolic reprogramming is a hallmark of cellular transformation, yet little is known about
metabolic changes that accompany tumor metastasis. Here we show that primary breast …

Naive T cells undergo metabolic reprogramming to support the increased energetic and
biosynthetic demands of effector T cell function. However, how nutrient availability …

Fructose intake has increased substantially throughout the developed world and is
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …