Mammalian motor behavior is enabled by a hierarchy of interleaved circuit modules
constructed by interneurons in the spinal cord, sensory feedback loops, and bilateral …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …

Autism spectrum disorder (ASD) is thought to result from deviation from normal development
of neural circuits and synaptic function. Many genes with mutation in ASD patients have …

A deletion on human chromosome 16p11. 2 is associated with autism spectrum disorders.
We deleted the syntenic region on mouse chromosome 7F3. MRI and high-throughput …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

Precise connectivity in neuronal circuits is a prerequisite for proper brain function. The
dauntingly complex environment encountered by axons and dendrites, even after navigation …

SETD1A encodes a histone methyltransferase whose de novo mutations are identified in
schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate …

Objective—The persistence of myeloid-derived cells in the artery wall is a characteristic of
advanced atherosclerotic plaques. However, the mechanisms by which these cells are …