Evolutionary medicine, which integrates evolutionary biology and medicine, significantly
enhances our understanding of human traits and disease susceptibility. However, previous …

The nucleolus is a major subnuclear compartment where ribosomal DNA (rDNA) is
transcribed and ribosomes are assembled. In addition, recent studies have shown that the …

Abstract Analysis of genome-scale evolution has been difficult in large, endangered animals
because opportunities to collect high-quality genetic samples are limited. There is a need for …

Accurate genome assemblies are essential for biological research, but even the highest
quality assemblies retain errors caused by the technologies used to construct them. Base …

Short tandem repeats (STRs) are widespread, repetitive elements, with a number of
biological functions and are among the most rapidly mutating regions in the genome. Their …

Non-canonical (non-B) DNA structures--bent DNA, slipped-strand structures, palindromes
and hairpins, triplex DNA, G-quadruplexes, etc.--which form at certain sequence motifs (A …

Motivation We are now in the era of being able to routinely generate highly contiguous (near
telomere-to-telomere) genome assemblies of human and nonhuman species. Complex …

All great apes differ karyotypically from humans due to the fusion of chromosomes 2a and
2b, resulting in human chromosome 2. Yet, the structure, function, and evolutionary history of …

Genomic drivers of human-specific neurological traits remain largely undiscovered.
Duplicated genes expanded uniquely in the human lineage likely contributed to brain …

Great apes have maintained a stable karyotype with few large-scale rearrangements; in
contrast, gibbons have undergone a high rate of chromosomal rearrangements coincident …