In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

The Banting Medal for Scientific Achievement Award is the American Diabetes Association's
highest scientific award and honors an individual who has made significant, long-term …

Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control
of body weight. The plasma concentrations are correlated with body mass index, and are …

Pancreatic β cells couple nutrient metabolism with appropriate insulin secretion. Here, we
show that pyruvate kinase (PK), which converts ADP and phosphoenolpyruvate (PEP) into …

Ca2+ signaling in mitochondria is important to tune mitochondrial function to a variety of
extracellular stimuli. The main mechanism is Ca2+ entry in mitochondria via the Ca2+ …

The hypothesis proposing that anaplerosis and cataplerosis play an important role in fuel
signaling by providing mitochondrially derived coupling factors for stimulation of insulin …

Pancreatic β-cells possess an inherent ability to generate oscillatory signals that trigger
insulin release. Coordination of the secretory activity among β-cells results in pulsatile …

This paper reviews the model of the control of mitochondrial substrate oxidation by Ca 2+
ions. The mechanism is the activation by Ca 2+ of four mitochondrial dehydrogenases, viz …

Impairment of insulin secretion from the β-cells of the pancreatic islets of Langerhans is
central to the development of type 2 diabetes mellitus and has therefore been the subject of …