Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Major depression is one of the most prevalent and debilitating personal and public health
conditions worldwide. Less appreciated is that depression's tremendous burdens are not …

Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …

Women are about twice as likely as are men to develop depression during their lifetime. This
Series paper summarises evidence regarding the epidemiology on gender differences in …

The gut microbiota interacts with the host via neuroimmune, neuroendocrine and neural
pathways. These pathways are components of the brain-gut-microbiota axis and preclinical …

Objectives: To provide guidance for the management of mood disorders, based on scientific
evidence supplemented by expert clinical consensus and formulate recommendations to …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

Depression presents in roughly 20% of people with diabetes worldwide, and adversely
affects quality of life and treatment outcomes. The causes of depression in diabetes are …

We examined the efficacy and acceptability of non-invasive brain stimulation in adult
unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct …