Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

There are functional benefits to exercise in muscle, even when performed late in life, but the
contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using …

Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …

Exercise and physical activity induces physiological responses in organisms, and
adaptations in skeletal muscle, which is beneficial for maintaining health and preventing …

Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …