It has been 50 years since Francis Fontan pioneered the operation that today bears his
name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a …

Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for
patients with severe heart failure. Different devices are available, and many—sometimes …

The mock circulatory loop (MCL) is an in vitro experimental system that can provide
continuous pulsatile flows and simulate different physiological or pathological parameters of …

The management of congenital heart disease has changed dramatically over the last 15
years and continues to evolve at a rapid pace. More than ever before contemporary practice …

Objective Fontan circulatory inefficiency can be addressed by replacing the missing
subpulmonary power source to reverse the Fontan paradox. An implantable cavopulmonary …

Fontan surgery represents a milestone in the evolution of congenital heart disease
management. It achieved the seemingly improbable (ie, restoration of a noncyanotic state by …

While the Fontan operation has facilitated the survival of a generation of children born with
congenital heart disease resulting in a functional single ventricle, it does not recreate a …

OBJECTIVE: The anatomic and physiologic constraints for pediatric cavopulmonary assist
differ markedly from adult Fontan circulations owing to smaller vessel sizes and risk of …

Mathematical modeling is a powerful tool to investigate hemodynamics of the circulatory
system. With improving imaging techniques and detailed clinical investigations, it is now …

Not many decades ago, it was the rare patient with a functionally univentricular heart who
survived to adulthood. 1 While this grim prognosis has gradually improved over the years …