Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis.
The rates of protein synthesis are primarily dependent on translational efficiency and …

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health
and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity …

Background The effect of concurrent training on the development of maximal strength is
unclear, especially in individuals with different training statuses. Objective The aim of this …

Key points For individuals showing suboptimal adaptations to resistance training,
manipulation of training volume is a potential measure to facilitate responses. This remains …

Many systemic diseases are featured by muscle atrophy. Cellular proteins are modified by
covalent attachment to a small protein known as ubiquitin (Ub) through ubiquitination. This …

Background Whole muscle hypertrophy does not appear to be negatively affected by
concurrent aerobic and strength training compared to strength training alone. However …

Protein synthesis is deemed the underpinning mechanism enhancing protein balance
required for skeletal muscle hypertrophy in response to resistance exercise. The current …

Post-exercise cold-water immersion (CWI) is used extensively in exercise training as a
means to minimise fatigue and expedite recovery between sessions. However, debate exists …