Production of recombinant and therapeutic proteins in microalgae

A Banerjee, V Ward - Current Opinion in Biotechnology, 2022 - Elsevier
Highlights•Microalgae based protein expression systems are highly promising.•
Chlamydomonas reinhardtii and Phaetodactylum tricornutum are the most prevalent species …

Microalgae as an efficient vehicle for the production and targeted delivery of therapeutic glycoproteins against SARS-CoV-2 variants

J Dehghani, A Movafeghi, E Mathieu-Rivet… - Marine drugs, 2022 - mdpi.com
Severe acute respiratory syndrome–Coronavirus 2 (SARS-CoV-2) can infect various human
organs, including the respiratory, circulatory, nervous, and gastrointestinal ones. The virus is …

Production and secretion of functional SARS-CoV-2 spike protein in Chlamydomonas reinhardtii

AM Kiefer, J Niemeyer, A Probst, G Erkel… - Frontiers in plant …, 2022 - frontiersin.org
The spike protein is the major protein on the surface of coronaviruses. It is therefore the
prominent target of neutralizing antibodies and consequently the antigen of all currently …

Can algae contribute to the war with Covid-19?

WY Chia, H Kok, KW Chew, SS Low, PL Show - Bioengineered, 2021 - Taylor & Francis
The world at large is facing a new threat with the emergence of the Coronavirus Disease
2019 (COVID-19) pandemic. Though imperceptible by the naked eye, the medical …

An insight to the therapeutic potential of algae-derived sulfated polysaccharides and polyunsaturated fatty acids: Focusing on the COVID-19

K Ziyaei, Z Ataie, M Mokhtari, K Adrah… - International Journal of …, 2022 - Elsevier
Covid-19 pandemic severely affected human health worldwide. The rapidly increasing
COVID-19 cases and successive mutations of the virus have made it a major challenge for …

Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics

SS Slattery, DJ Giguere, EE Stuckless, A Shrestha… - Scientific reports, 2022 - nature.com
The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has
highlighted the need for a synthetic biology approach to create reliable and scalable …

Modern advancement in biotechnological applications for wastewater treatment through microalgae: a review

S Goyal, R Dhanker, T Hussain, A Ferreira… - Water, Air, & Soil …, 2023 - Springer
Microalgae are microscopic organisms that have a broad range of applications, from
wastewater treatment, CO2 mitigation to therapeutic proteins, and pharmaceuticals …

Harnessing the algal chloroplast for heterologous protein production

EA Cutolo, G Mandalà, L Dall'Osto, R Bassi - Microorganisms, 2022 - mdpi.com
Photosynthetic microbes are gaining increasing attention as heterologous hosts for the light-
driven, low-cost production of high-value recombinant proteins. Recent advances in the …

The red alga Porphyridium as a host for molecular farming: Efficient production of immunologically active hepatitis C virus glycoprotein

A Hammel, LM Cucos, I Caras… - Proceedings of the …, 2024 - National Acad Sciences
Microalgae are promising production platforms for the cost-effective production of
recombinant proteins. We have recently established that the red alga Porphyridium …

Recent advances in the bio-application of microalgae-derived biochemical metabolites and development trends of photobioreactor-based culture systems

SF Khaligh, A Asoodeh - 3 Biotech, 2022 - Springer
Microalgae are microscopic algae in sizes ranging from a few micrometers to several
hundred micrometers. On average, half of the oxygen in the atmosphere is produced by the …