Under stressful conditions, the hypothalamic-pituitary-adrenal (HPA) axis acts to promote
transitory physiological adaptations that are often resolved after the stressful stimulus is no …

Like other classes of treatments described in this issue's section, neuroactive steroids have
been studied for decades but have risen as a new class of rapid-acting, durable …

The activity of neurons in the rodent hippocampus contributes to diverse behaviors, with the
activity of ventral hippocampal neurons affecting behaviors related to anxiety and emotion …

Aim To evaluate the efficacy and safety of an oral, once‐daily, 14‐day treatment course of
zuranolone in Japanese patients with major depressive disorder (MDD). Methods This …

Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high
worldwide prevalence and serious long-term negative outcomes for both mothers and …

Even though major depressive disorder (MDD) and post-traumatic stress disorder (PTSD)
are among the most prevalent and incapacitating mental illnesses in the world, their …

Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors, or GABAkines,
play important roles in the treatment of depression, epilepsy, insomnia, and other disorders …

Fibrinolysis occurs when plasminogen activators, such as tissue plasminogen activator
(tPA), convert plasminogen to plasmin, which dissolves the fibrin clot. The proteolytic activity …

Pre-natal exposure to acute maternal trauma or chronic maternal distress can confer
increased risk for psychiatric disorders in later life. Acute maternal trauma is the result of …

The purpose of the study was to examine whether the underlying mechanism of the
alteration of cognitive ability and synaptic plasticity induced by the housing environment is …