NMR hyperpolarization techniques of gases

DA Barskiy, AM Coffey, P Nikolaou… - … A European Journal, 2017 - Wiley Online Library
Nuclear spin polarization can be significantly increased through the process of
hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance …

[HTML][HTML] In vivo methods and applications of xenon-129 magnetic resonance

H Marshall, NJ Stewart, HF Chan, M Rao… - Progress in Nuclear …, 2021 - Elsevier
Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the
ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed …

Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe …

PJ Niedbalski, CS Hall, M Castro… - Magnetic resonance …, 2021 - Wiley Online Library
Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Functional imaging of the lungs with gas agents

SJ Kruger, SK Nagle, MJ Couch, Y Ohno… - Journal of Magnetic …, 2016 - Wiley Online Library
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved‐phase MRI

K Qing, JP Mugler III, TA Altes, Y Jiang… - NMR in …, 2014 - Wiley Online Library
Magnetic‐resonance spectroscopy and imaging using hyperpolarized xenon‐129 show
great potential for evaluation of the most important function of the human lung‐‐gas …

Measuring diffusion limitation with a perfusion-limited gas—Hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis

SS Kaushik, MS Freeman, SW Yoon… - Journal of applied …, 2014 - journals.physiology.org
Although xenon is classically taught to be a “perfusion-limited” gas, 129Xe in its
hyperpolarized (HP) form, when detected by magnetic resonance (MR), can probe diffusion …

Experimental validation of the hyperpolarized 129Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease

NJ Stewart, G Leung, G Norquay… - Magnetic resonance …, 2015 - Wiley Online Library
Purpose To assess the sensitivity of the hyperpolarized 129Xe chemical shift saturation
recovery (CSSR) technique for noninvasive quantification of changes to lung microstructure …

Translational applications of hyperpolarized 3He and 129Xe

LL Walkup, JC Woods - NMR in Biomedicine, 2014 - Wiley Online Library
Clinical magnetic resonance imaging of the lung is technologically challenging, yet over the
past two decades hyperpolarized noble gas (3He and 129Xe) imaging has demonstrated …

Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three‐dimensional steady‐state free precession

NJ Stewart, G Norquay, PD Griffiths… - Magnetic resonance in …, 2015 - Wiley Online Library
Purpose To demonstrate the potential for high quality MRI of pulmonary ventilation using
naturally abundant xenon (NAXe) gas. Methods MRI was performed at 1.5 Tesla (T) and 3 T …

Magnetic resonance imaging with hyperpolarized agents: methods and applications

EB Adamson, KD Ludwig, DG Mummy… - Physics in Medicine & …, 2017 - iopscience.iop.org
In the past decade, hyperpolarized (HP) contrast agents have been under active
development for MRI applications to address the twin challenges of functional and …