Treatment of pulmonary arterial hypertension: recent progress and a look to the future

M Humbert, O Sitbon, C Guignabert… - The Lancet …, 2023 - thelancet.com
Pulmonary arterial hypertension (PAH) is a severe but treatable form of pre-capillary
pulmonary hypertension caused by pulmonary vascular remodelling. As a result of basic …

[HTML][HTML] Pathophysiology and new advances in pulmonary hypertension

S Bousseau, RS Fais, S Gu, A Frump, T Lahm - BMJ medicine, 2023 - ncbi.nlm.nih.gov
Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition
characterised by increased pulmonary arterial pressure, structural changes in the pulmonary …

Macrophage–NLRP3 activation promotes right ventricle failure in pulmonary arterial hypertension

R Al-Qazazi, PDA Lima, SZ Prisco, F Potus… - American journal of …, 2022 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular
failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin …

Vascular remodeling in pulmonary arterial hypertension: the potential involvement of innate and adaptive immunity

R Tobal, J Potjewijd, VPM Empel, R Ysermans… - Frontiers in …, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe disease with high morbidity and mortality.
Current therapies are mainly focused on vasodilative agents to improve prognosis …

Pulmonary hypertension: Linking inflammation and pulmonary arterial stiffening

SF Liu, N Nambiar Veetil, Q Li… - Frontiers in …, 2022 - frontiersin.org
Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

Pulmonary arterial hypertension associated with connective tissue diseases (CTD-PAH): Recent and advanced data

B Thoreau, L Mouthon - Autoimmunity Reviews, 2024 - Elsevier
Pulmonary arterial hypertension (PAH), corresponding to group 1 of pulmonary
hypertension classification, is a rare disease with a major prognostic impact on morbidity …

Genetics and precision genomics approaches to pulmonary hypertension

ED Austin, MA Aldred, M Alotaibi… - European …, 2024 - publications.ersnet.org
Considerable progress has been made in the genomics of pulmonary arterial hypertension
(PAH) since the 6th World Symposium on Pulmonary Hypertension, with the identification of …

New drugs and therapies in pulmonary arterial hypertension

AJ Shah, T Beckmann, M Vorla, DK Kalra - International Journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension is a chronic, progressive disorder of the pulmonary
vasculature with associated pulmonary and cardiac remodeling. PAH was a uniformly fatal …

Pulmonary vascular fibrosis in pulmonary hypertension–The role of the extracellular matrix as a therapeutic target

K Jandl, N Radic, K Zeder, G Kovacs… - Pharmacology & …, 2023 - Elsevier
Pulmonary hypertension (PH) is a condition characterized by changes in extracellular matrix
(ECM) deposition and vascular remodeling of distal pulmonary arteries. These changes …

Interleukin-6 and pulmonary hypertension: from physiopathology to therapy

WJ Xu, Q Wu, WN He, S Wang, YL Zhao… - Frontiers in …, 2023 - frontiersin.org
Pulmonary hypertension (PH) is a progressive, pulmonary vascular disease with high
morbidity and mortality. Unfortunately, the pathogenesis of PH is complex and remains …