Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is
challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and …

Abstract Background Cancer stem cells (CSCs) are strongly associated with high
tumourigenicity, chemotherapy or radiotherapy resistance, and metastasis and recurrence …

Context Lung cancer, the most common type of cancer, has a high mortality rate.
Cucurbitacin B (CuB), a natural compound extracted from Cucurbitaceae plants, has …

Gastric cancer is the third most common cause of cancer-related death worldwide. Drug
resistance is the main inevitable and vital factor leading to a low 5-year survival rate for …

Colorectal cancer is the third most common and the second deadliest cancer worldwide. To
date, colorectal cancer becomes one of the most important challenges of the health system …

Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae
family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and …

The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110
years ago and has been found to play a crucial role in the development of multicellular …

Simple Summary Bitter taste receptors (TAS2Rs) are functionally expressed in various extra-
oral cells eliciting non-gustatory functions. In the context of cancer, their functionality is less …