Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF).
These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an …

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical
drawback as each disease interferes with the treatment of the other. In addition to shared …

Background: Accumulating evidence suggests that the failing heart reprograms fuel
metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference
from glucose to fatty acids for postnatal energy production,. This adaptation is triggered in …

L-aspartate (Asp) serves as a central building block, in addition to being a constituent of
proteins, for many metabolic processes in most organisms, such as biosynthesis of other …

Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …