Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …

Epidemiological studies link fructose consumption with metabolic disease, an association
attributable in part to fructose-mediated lipogenesis. The mechanisms governing fructose …

Recent findings have shown an inverse association between circulating C15: 0/C17: 0 fatty
acids with disease risk, therefore, their origin needs to be determined to understanding their …

High-fructose intake in healthy men is associated with characteristics of metabolic
syndrome. Extensive knowledge exists about the differences between hepatic fructose and …

Type 2 diabetes (T2D) is a metabolic disease characterized by obesity, insulin resistance,
and the dysfunction of several key glucoregulatory organs. Among these organs, impaired …

Liver glucose metabolism is dependent on glucokinase activity. Glucokinase expression is
transcriptionally regulated by hormones and metabolites of glucose, and glucokinase activity …

Background/Objectives: The diverse effects of fructose and glucose on the progression of
metabolic dysfunction-associated steatotic liver disease remain uncertain. This study …

Insulin resistanceis interpreted as being a normal or raised insulin level giving rise to a
biological reaction which is attenuated in effect; classically this cites to the weakened …