Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
The role of reactive oxygen species in the pathogenesis of Alzheimer's disease, Parkinson's disease, and Huntington's disease: a mini review
S Manoharan, GJ Guillemin… - Oxidative medicine …, 2016 - Wiley Online Library
Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …
their life spans. All forms of neurodegenerative diseases have a massive impact on the …
Alpha-synuclein oligomers: a new hope
N Bengoa-Vergniory, RF Roberts, R Wade-Martins… - Acta …, 2017 - Springer
Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …
main pathological drivers in the disease, although it remains unclear how this protein elicits …
Biological metals and metal-targeting compounds in major neurodegenerative diseases
KJ Barnham, AI Bush - Chemical Society Reviews, 2014 - pubs.rsc.org
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
An integrative approach to ortholog prediction for disease-focused and other functional studies
Background Mapping of orthologous genes among species serves an important role in
functional genomics by allowing researchers to develop hypotheses about gene function in …
functional genomics by allowing researchers to develop hypotheses about gene function in …
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
J Bieschke, J Russ, RP Friedrich… - Proceedings of the …, 2010 - National Acad Sciences
Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to
cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's …
cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's …
Molecular mechanisms and potential therapeutical targets in Huntington's disease
C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
DE Ehrnhoefer, J Bieschke, A Boeddrich… - Nature structural & …, 2008 - nature.com
The accumulation of β-sheet–rich amyloid fibrils or aggregates is a complex, multistep
process that is associated with cellular toxicity in a number of human protein misfolding …
process that is associated with cellular toxicity in a number of human protein misfolding …
Toward the molecular mechanism (s) by which EGCG treatment remodels mature amyloid fibrils
FL Palhano, J Lee, NP Grimster… - Journal of the American …, 2013 - ACS Publications
Protein misfolding and/or aggregation has been implicated as the cause of several human
diseases, such as Alzheimer's and Parkinson's diseases and familial amyloid …
diseases, such as Alzheimer's and Parkinson's diseases and familial amyloid …
Nutraceutical antioxidants as novel neuroprotective agents
NA Kelsey, HM Wilkins, DA Linseman - Molecules, 2010 - mdpi.com
A variety of antioxidant compounds derived from natural products (nutraceuticals) have
demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell …
demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell …