Covering: 2005 to 2013 This review focuses on recent applications of the aza-Michael
reaction in alkaloids total synthesis with a special emphasis on stereoselectivity. The report …

The Mannich reaction has been widely used to effectively construct C–N and C–C bonds in
organic synthesis. This review focuses on selected applications of the intramolecular …

The expanding “toolbox” of biocatalysts opens new opportunities to redesign synthetic
strategies to target molecules by incorporating a key enzymatic step into the synthesis …

In this study, we unveil the versatility of 4-pentyn-1-ols as carbonyl surrogates for the
unprecedented synthesis of diverse oxygen heterocycles, including [5, 6, 5]-bis-spiroketals …

The use of chiral sulfinyl amines both as nucleophilic nitrogen sources and chiral inducers
has been described for the first time in a desymmetrization-type process involving an …

For the first time, uncatalyzed, high‐pressure (0.6 GPa) reactions with ketones have proven
to be a powerful way to perform the three‐component Strecker synthesis of α‐amino nitriles …

Covering: July 2004 to June 2005This review covers the isolation, structure determination,
synthesis, chemical transformations and biological activity of indolizidine and quinolizidine …

An organocatalytic enantioselective intramolecular aza-Michael reaction has been
described for the first time in a desymmetrization process employing substrates different from …

An aza-[3+ 3] annulation or formal cycloaddition strategy for constructing complex
heterocycles, chiefly alkaloids, is reviewed here. This annulation involves a Knoevenagel …

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio-
and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+ 2] …