Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Blood and lymphatic vessels form a versatile transport network and provide inductive signals
to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and …

INTRODUCTION Resident tissue macrophages (RTMs) are a heterogeneous population of
immune cells occupying multiple tissue niches and exhibiting microenvironment-specific …

The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

The maintenance of appropriate arterial tone is critically important for normal physiological
arterial function. However, the cellular and molecular mechanisms remain poorly defined …

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that
occupies tissues without recirculating. They provide a first response against infections …

The developmental and molecular heterogeneity of tissue macrophages is unravelling, as
are their diverse contributions to physiology and pathophysiology. Moreover, also given …

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …