The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of
the cells have a direct effect on cells' behaviour and subsequently on clinical outcomes …

Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …

Protocols have been established to direct the differentiation of human induced pluripotent
stem (iPS) cells into nephron progenitor cells and organoids containing many types of …

Engineering the surface chemistry of a material so that it can interface with cells is an
extraordinarily demanding task. The surface of a cell is composed of thousands of different …

Human embryonic stem cells and induced pluripotent stem cells have great potential in
research and therapies. The current in vitro culture systems for human pluripotent stem cells …

Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells.
Understanding of the functions of these markers is critical for characterization and …

To exploit the full potential of human pluripotent stem cells for regenerative medicine,
developmental biology and drug discovery, defined culture conditions are needed. Media of …

The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …

Physical stimuli can act in either a synergistic or antagonistic manner to regulate cell fate
decisions, but it is less clear whether insoluble signals alone can direct human pluripotent …