[HTML][HTML] Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
[HTML][HTML] Innate metabolic responses against viral infections
CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …
disease. At the systemic level, a significant feature of viral infection and inflammation that …
[HTML][HTML] Multiple early factors anticipate post-acute COVID-19 sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
[HTML][HTML] Cellular and molecular biomarkers of long COVID: a scoping review
Summary Background Long-COVID (LC) encompasses diverse symptoms lasting months
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …
[HTML][HTML] Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19
T Matsuyama, SK Yoshinaga, K Shibue… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …
develop our understanding of the nature of the disease and its effects on human immunity …
Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Using a high-throughput mitochondrial phenotyping platform to quantify multiple
mitochondrial features among molecularly defined immune cell subtypes, we quantify the …
mitochondrial features among molecularly defined immune cell subtypes, we quantify the …
[HTML][HTML] Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
[HTML][HTML] Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. Here,
we perform longitudinal blood sampling of ESKD haemodialysis patients with COVID-19 …
we perform longitudinal blood sampling of ESKD haemodialysis patients with COVID-19 …
Coronavirus disease 2019 (COVID‐19) update: From metabolic reprogramming to immunometabolism
M Rudiansyah, SA Jasim… - Journal of Medical …, 2022 - Wiley Online Library
The field of immunometabolism investigates and describes the effects of metabolic rewiring
in immune cells throughout activation and the fates of these cells. Recently, it has been …
in immune cells throughout activation and the fates of these cells. Recently, it has been …
[HTML][HTML] Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine
RNA-based vaccines against SARS-CoV-2 have proven critical to limiting COVID-19
disease severity and spread. Cellular mechanisms driving antigen-specific responses to …
disease severity and spread. Cellular mechanisms driving antigen-specific responses to …