Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
[HTML][HTML] Telomeres: history, health, and hallmarks of aging
The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
From NASH to HCC: current concepts and future challenges
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Molecular therapies and precision medicine for hepatocellular carcinoma
The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …
an annual incidence of 1 million cases. Genomic studies have established the landscape of …
Advances in molecular classification and precision oncology in hepatocellular carcinoma
S Rebouissou, JC Nault - Journal of hepatology, 2020 - Elsevier
Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
[HTML][HTML] Integrated proteogenomic characterization of HBV-related hepatocellular carcinoma
We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related
hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 …
hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 …
Trial design and endpoints in hepatocellular carcinoma: AASLD consensus conference
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide.(1, 2) This neoplasm has some unique characteristics. It occurs in most cases …
worldwide.(1, 2) This neoplasm has some unique characteristics. It occurs in most cases …
Convergent somatic mutations in metabolism genes in chronic liver disease
SWK Ng, FJ Rouhani, SF Brunner, N Brzozowska… - Nature, 2021 - nature.com
The progression of chronic liver disease to hepatocellular carcinoma is caused by the
acquisition of somatic mutations that affect 20–30 cancer genes,,,,,,–. Burdens of somatic …
acquisition of somatic mutations that affect 20–30 cancer genes,,,,,,–. Burdens of somatic …