Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
MR Pinzone, DJ VanBelzen, S Weissman… - Nature …, 2019 - nature.com
After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a
long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues …
long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues …
SARS-CoV-2 spike 1 protein controls natural killer cell activation via the HLA-E/NKG2A pathway
Natural killer cells are important in the control of viral infections. However, the role of NK
cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has …
cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has …
Hepatitis B virus adaptation to the CD8+ T cell response: consequences for host and pathogen
Chronic viral hepatitis infections are a major public health concern, with an estimated 290
million individuals infected with hepatitis B virus (HBV) globally. This virus has been a …
million individuals infected with hepatitis B virus (HBV) globally. This virus has been a …
Conserved and variable natural killer cell receptors: diverse approaches to viral infections
LY Bastidas‐Legarda, SI Khakoo - Immunology, 2019 - Wiley Online Library
Natural killer (NK) cells are lymphocytes of the innate immune system with essential roles
during viral infections. NK cell functions are mediated through a repertoire of non …
during viral infections. NK cell functions are mediated through a repertoire of non …
Nef proteins from HIV-1 elite controllers are inefficient at preventing antibody-dependent cellular cytotoxicity
Impairment of Nef function, including reduced CD4 downregulation, was described in a
subset of HIV-1-infected individuals that control viral replication without antiretroviral …
subset of HIV-1-infected individuals that control viral replication without antiretroviral …
Gene expression profiling of SARS-CoV-2 infections reveal distinct primary lung cell and systemic immune infection responses that identify pathways relevant in …
To identify key gene expression pathways altered with infection of the novel coronavirus
SARS-CoV-2, we performed the largest comparative genomic and transcriptomic analysis to …
SARS-CoV-2, we performed the largest comparative genomic and transcriptomic analysis to …
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes
Background The highly genetically diverse HIV-1 group M subtypes may differ in their
biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a …
biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a …
[HTML][HTML] Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro
Eradication of the HIV-1 latent reservoir represents the current paradigm to developing a
cure for AIDS. HIV-1 has evolved multiple mechanisms to evade CD8 T cell responses …
cure for AIDS. HIV-1 has evolved multiple mechanisms to evade CD8 T cell responses …
Impaired Nef function is associated with early control of HIV-1 viremia
XT Kuang, X Li, G Anmole, P Mwimanzi… - Journal of …, 2014 - Am Soc Microbiol
Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been
observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of …
observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of …
[HTML][HTML] COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments
I Gilyazova, Y Timasheva, A Karunas… - Non-coding RNA …, 2023 - Elsevier
The novel coronavirus infection (COVID-19) causes a severe acute illness with the
development of respiratory distress syndrome in some cases. COVID-19 is a global problem …
development of respiratory distress syndrome in some cases. COVID-19 is a global problem …