Mosquito salivary proteins and arbovirus infection: from viral enhancers to potential targets for vaccines

A Marín-López, H Raduwan, TY Chen, S Utrilla-Trigo… - Pathogens, 2023 - mdpi.com
Arthropod-borne viruses present important public health challenges worldwide. Viruses
such as DENV, ZIKV, and WNV are of current concern due to an increasing incidence and …

Current vector research challenges in the greater Mekong subregion for dengue, Malaria, and Other Vector-Borne Diseases: A report from a multisectoral workshop …

RC Christofferson, DM Parker… - PLoS neglected …, 2020 - journals.plos.org
Vector-borne diseases (VBDs) are a significant and growing threat to the health of the 326
million people living in the Greater Mekong Subregion (GMS)(Fig 1). The GMS is a diverse …

Development of Inapparent Dengue Associated With Increased Antibody Levels to Aedes aegypti Salivary Proteins: A Longitudinal Dengue Cohort in Cambodia

JE Manning, S Chea, DM Parker, JA Bohl… - The Journal of …, 2022 - academic.oup.com
Background We established the first prospective cohort to understand how infection with
dengue virus is influenced by vector-specific determinants such as humoral immunity to …

IgG Antibody Responses to the Aedes albopictus 34k2 Salivary Protein as Novel Candidate Marker of Human Exposure to the Tiger Mosquito

S Buezo Montero, P Gabrieli, F Montarsi… - Frontiers in Cellular …, 2020 - frontiersin.org
Mosquitoes of the Aedes genus transmit arboviruses of great importance to human health as
dengue, chikungunya, Zika and yellow fever. The tiger mosquito Aedes albopictus can play …

EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral …

MH Collins, GE Potter, MDT Hitchings, E Butler… - Trials, 2022 - Springer
Abstract Background Arboviruses transmitted by Aedes aegypti including dengue, Zika, and
chikungunya are a major global health problem, with over 2.5 billion at risk for dengue …

Multiple Salivary Proteins from Aedes aegypti Mosquito Bind to the Zika Virus Envelope Protein

PC Valenzuela-Leon, G Shrivastava, I Martin-Martin… - Viruses, 2022 - mdpi.com
Aedes aegypti mosquitoes are important vectors of several debilitating and deadly arthropod-
borne (arbo) viruses, including Yellow Fever virus, Dengue virus, West Nile virus and Zika …

Antibodies to Aedes spp. salivary proteins: a systematic review and pooled analysis

V Etienne, A Gallagher, RC Christofferson… - Frontiers in Tropical …, 2023 - frontiersin.org
Aedes spp. mosquitos are responsible for transmitting several viruses that pose significant
public health risks, including dengue, Zika, yellow fever, chikungunya, and West Nile …

Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes

PH Alvarenga, DR Dias, X Xu, IMB Francischetti… - Insect biochemistry and …, 2022 - Elsevier
The D7 proteins are highly expressed in the saliva of hematophagous Nematocera and bind
biogenic amines and eicosanoid compounds produced by the host during blood feeding …

IgG1 and IgG4 antibodies against Aedes aegypti salivary proteins and risk for dengue infections

JC Cardenas, PM Drame, KA Luque-Burgos… - PLoS …, 2019 - journals.plos.org
Dengue virus (DENV) is an arbovirus responsible for a significant number of deaths in Latin
America. This virus is transmitted through the bite of Aedes aegypti, the main mosquito …

Serologic tools and strategies to support intervention trials to combat Zika virus infection and disease

MH Collins - Tropical Medicine and Infectious Disease, 2019 - mdpi.com
Zika virus is an emerging mosquito-borne flavivirus that recently caused a large epidemic in
Latin America characterized by novel disease phenotypes, including Guillain-Barré …